Prognosis of patients treated in a single neurosurgical reference centre for brain metastasis caused by dormant disseminated cells.

ABSTRACT: Brain metastasis (BM) is a frequent complication of systemic cancer usually associated with poor prognosis. Survival depends on numerous factors, which complicates prognosis and treatment. It has been suggested that BM growing from previously dormant disseminated tumour cells (DTCs) may exhibit a milder phenotype than BM derived from continuously progressing metastatic cells; however, to the best of our knowledge, the prognosis of patients presenting with BM from dormant DTCs is unknown. The present study retrospectively compared survival data, collected from a single neurosurgical centre, between patients presenting with BM from previously dormant DTCs and patients with non-dormant BM. A total of 262 medical records were reviewed. In the univariate Cox regression analysis, the median surv

SUBMITTER: Ferlini L 

PROVIDER: S-EPMC8063273 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature