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Decline of Orientation and Direction Sensitivity in the Aging Population.

ABSTRACT: While the aging population is growing, our knowledge regarding age-related deterioration of visual perception remains limited. In the present study, we investigated the effects of aging on orientation and direction sensitivity in a healthy population using a weighted up-down adaptive method to improve the efficiency and reliability of the task. A total of 57 healthy participants aged 22-72 years were included and divided into old and young groups. Raw experimental data were processed using a psychometric method to determine the differences between the two groups. In the orientation task, the threshold of the discrimination angle and bias (i.e., the difference between the perceived midpoint from the logistic function and the reference point) was increased, while the lapsing rate (i.e., 1-the maximum logistic function) did not significantly change in the old group compared with the young group. In the motion direction task, the threshold, bias, and lapsing rate were significantly increased in the old group compared with the young group. These results suggest that the decreased ability of old participants in discrimination of stimulus orientation and motion direction could be related to the impaired function of visual cortex.

SUBMITTER: Xia L

PROVIDER: S-EPMC8064032 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:IntroductionSubjective cognitive decline is a self-reported measure of worsening memory and day-to-day decision making. Cognitive decline may impair an individual's ability to complete instrumental activities of daily living (IADL) such as preparing meals or taking medication, ultimately limiting one's ability to live independently. People with IADL impairments typically rely on informal care from spouses or children. Interpersonal and structural discrimination towards sexual minority (SM, including lesbian, gay, bisexual, and other queer identified) populations may contribute to disparities in cognitive decline and informal care outcomes.ObjectiveEstimate differences in prevalence, severity, and receipt of social support for subjective cognitive decline stratified by sex and SM status.MethodsCross-sectional study design using a probability sample (n = 172,047) from the Behavioral Risk Factor Surveillance System 2015-2019. Prevalence estimates and multivariable Poisson regression models were used to compare outcomes by sex and sexual identity.ResultsCompared to heterosexual peers, SM men and women were more likely to experience cognitive decline (15% of SM men, 11% of heterosexual men, 17% of SM women, 11% of heterosexual women). In adjusted models, SM women were 22% more likely (95%CI:3%-44%, p < .05) to report IADL impairments due to cognitive decline but were 17% less likely (95%CI:1%-31%, p < .05) to receive any social support with IADL impairments compared to heterosexual women. In adjusted models, SM men were 25% more likely (95%CI: 0%-56%, p < .05) to report IADL impairments due to cognitive decline but reported no significant difference in receiving social support with IADL impairments compared to heterosexual men.DiscussionWe identified significant unmet need for social supports for IADL impairments, with highest unmet need among SM women. Comprehensive strategies such as LGBTQ + affirming assisted living and home and community-based services are needed to ensure equity in receipt of long-term supports and services for SM populations.

Project description:Background/objectivesTo investigate potential mechanisms underlying the well-established relationship of diabetes and obesity with cognitive decline, among older adults participating in a population-based study.Design/settingTen-year population-based cohort study.ParticipantsA total of 478 individuals aged 65 years and older.MeasurementsWe assayed fasting blood for markers of glycemia (glucose and hemoglobin A1c [HbA1c]), insulin resistance (IR) (insulin and homeostatic model assessment of IR), obesity (resistin, adiponectin, and glucagon-like peptide-1), and inflammation (C-reactive protein). We modeled these indices as predictors of the slope of decline in global cognition, adjusting for age, sex, education, APOE*4 genotype, depressive symptoms, waist-hip ratio (WHR), and systolic blood pressure, in multivariable regression analyses of the entire sample and stratified by sex-specific median WHR. We then conducted WHR-stratified machine-learning (Classification and Regression Tree [CART]) analyses of the same variables.ResultsIn multivariable regression analyses, in the entire sample, HbA1c was significantly associated with cognitive decline. After stratifying by median WHR, HbA1c remained associated with cognitive decline in those with higher WHR. No metabolic indices were associated with cognitive decline in those with lower WHR. Cross-validated WHR-stratified CART analyses selected no predictors in participants older than 87 to 88 years. Faster cognitive decline was associated, in lower WHR participants younger than 87 years, with adiponectin of 11 or greater; and in higher WHR participants younger than 88 years, with HbA1c of 6.2% or greater.ConclusionsOur population-based data suggest that, in individuals younger than 88 years with central obesity, even modest degrees of hyperglycemia might independently predispose to faster cognitive decline. In contrast, among those younger than 87 years without central obesity, adiponectin may be a novel independent risk factor for cognitive decline. J Am Geriatr Soc 68:991-998, 2020.

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Decline of Orientation and Direction Sensitivity in the Aging Population.

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