Proteomics signature of autoimmune atrophic gastritis: towards a link with gastric cancer.

ABSTRACT:

Background

Autoimmune atrophic gastritis (AAG) is a chronic disease that can progress to gastric cancer (GC). To better understand AAG pathology, this proteomics study investigated gastric proteins whose expression levels are altered in this disease and also in GC.

Methods

Using two-dimensional difference gel electrophoresis (2D-DIGE), we compared protein maps of gastric corpus biopsies from AAG patients and controls. Differentially abundant spots (|fold change|≥ 1.5, P < 0.01) were selected and identified by LC-MS/MS. The spots were further assessed in gastric antrum biopsies from AAG patients (without and with Helicobacter pylori infection) and from GC patients and unaffected first-degree relatives of GC patients.

Results

2D-DIGE identified 67 differentially abundan

SUBMITTER: Repetto O 

PROVIDER: S-EPMC8064991 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature