Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection.

ABSTRACT: Inflammation during neonatal brain infections leads to significant secondary sequelae such as hydrocephalus, which often follows neonatal sepsis in the developing world. In 100 African hydrocephalic infants we identified the biological pathways that account for this response. The dominant bacterial pathogen was a Paenibacillus species, with frequent cytomegalovirus co-infection. A proteogenomic strategy was employed to confirm host immune response to Paenibacillus and to define the interplay within the host immune response network. Immune activation emphasized neuroinflammation, oxidative stress reaction, and extracellular matrix organization. The innate immune system response included neutrophil activity, signaling via IL-4, IL-12, IL-13, interferon, and Jak/STAT pathways. P

SUBMITTER: Isaacs AM 

PROVIDER: S-EPMC8065213 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature