Ontology highlight
ABSTRACT:
SUBMITTER: Ip CK
PROVIDER: S-EPMC8065287 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
STAR protocols 20210412 2
Chronic stress has adverse consequences on many organ systems and physiological processes. However, existing protocols show large variability in response and are not suitable for female mice. Here, we provide a step-by-step protocol for establishing a reliable chronic stress model in mice that can be used in a variety of physiological settings. This protocol has been tested to be effective to produce a consistent response to stress in several mouse strains (C57BL/6J, 129X1/SvJ, B6.V-Lepob/J) and ...[more]