Radiomic profiling of clear cell renal cell carcinoma reveals subtypes with distinct prognoses and molecular pathways.

ABSTRACT:

Background

To identify radiomic subtypes of clear cell renal cell carcinoma (ccRCC) patients with distinct clinical significance and molecular characteristics reflective of the heterogeneity of ccRCC.

Methods

Quantitative radiomic features of ccRCC were extracted from preoperative CT images of 160 ccRCC patients. Unsupervised consensus cluster analysis was performed to identify robust radiomic subtypes based on these features. The Kaplan-Meier method and chi-square test were used to assess the different clinicopathological characteristics and gene mutations among the radiomic subtypes. Subtype-specific marker genes were identified, and gene set enrichment analyses were performed to reveal the specific molecular characteristics of each subtype. Moreover, a gene expression-bas

SUBMITTER: Lin P 

PROVIDER: S-EPMC8065300 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature