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Osimertinib as neoadjuvant therapy in a patient with stage IIIA non-small cell lung cancer: a case report.


ABSTRACT:

Introduction

Tyrosine kinase inhibitors (TKI) targeting epidermal growth factor receptor (EGFR) are approved for use in metastatic non-small cell lung cancer (NSCLC).

Case presentation

Here we present a case of a African American patient with stage IIIA NSCLC treated with osimertinib in the neoadjuvant setting with concurrent radiation, followed by resection. The patient remains disease-free 4 months after surgery.

Conclusion

This case report suggests that osimertinib may be effective as neoadjuvant therapy in resectable stage III disease. Additionally, we provide a summary of previous case reports and ongoing clinical trials for neoadjuvant EGFR inhibition in stage III NSCLC patients.

SUBMITTER: Chen CY 

PROVIDER: S-EPMC8066434 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Osimertinib as neoadjuvant therapy in a patient with stage IIIA non-small cell lung cancer: a case report.

Chen Caroline Y CY   Fares Charlene M CM   Shin Daniel Sanghoon DS  

Journal of medical case reports 20210424 1


<h4>Introduction</h4>Tyrosine kinase inhibitors (TKI) targeting epidermal growth factor receptor (EGFR) are approved for use in metastatic non-small cell lung cancer (NSCLC).<h4>Case presentation</h4>Here we present a case of a African American patient with stage IIIA NSCLC treated with osimertinib in the neoadjuvant setting with concurrent radiation, followed by resection. The patient remains disease-free 4 months after surgery.<h4>Conclusion</h4>This case report suggests that osimertinib may b  ...[more]

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