Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A.
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ABSTRACT: We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up process. A more convenient and cost-efficient Keck asymmetric vinylogous aldol reaction was employed to improve this transformation.
SUBMITTER: Zhang T
PROVIDER: S-EPMC8066987 | biostudies-literature |
REPOSITORIES: biostudies-literature
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