Unknown

Dataset Information

0

Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A.


ABSTRACT: We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up process. A more convenient and cost-efficient Keck asymmetric vinylogous aldol reaction was employed to improve this transformation.

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8066987 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5817386 | biostudies-literature
| S-EPMC4754294 | biostudies-literature
| S-EPMC3509943 | biostudies-literature
| S-EPMC2989683 | biostudies-literature
2022-04-24 | GSE193033 | GEO
| S-EPMC3497871 | biostudies-other
| S-EPMC7497793 | biostudies-literature
| S-EPMC4613946 | biostudies-literature
| S-EPMC7801535 | biostudies-literature
| S-EPMC9483285 | biostudies-literature