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Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis.

ABSTRACT: Aspergillus spp. are spore forming molds; a subset of which are clinically relevant to humans and can cause significant morbidity and mortality. A. fumigatus causes chronic infection in patients with chronic lung disease such as asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). In patients with CF, A. fumigatus infection can lead to allergic disease, such as allergic bronchopulmonary aspergillosis (ABPA) which is associated with high rates of hospitalizations for acute exacerbations and lower lung function. ABPA results from T_H2 immune response to Aspergillus antigens produced during hyphal growth, marked by high levels of IgE and eosinophil activation. Clinically, patients with ABPA experience difficulty breathing; exacerbations of disease and are at high risk for bronchiectasis and lung fibrosis. Oral corticosteroids are used to manage aspects of the inflammatory response and antifungal agents are used to reduce fungal burden and lower the exposure to fungal antigens. As the appreciation for the severity of fungal infections has grown, new therapies have emerged that aim to improve treatment and outcomes for patients with CF.

SUBMITTER: Curran AK

PROVIDER: S-EPMC8067098 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.

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| S-EPMC5399694 | biostudies-literature

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2020-10-30 | GSE139943 | GEO

Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis.

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Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.

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| S-EPMC3122734 | biostudies-literature

CFTR Modulators Dampen <i>Aspergillus</i>-Induced Reactive Oxygen Species Production by Cystic Fibrosis Phagocytes.

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| S-EPMC9724814 | biostudies-literature

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