Ontology highlight
ABSTRACT:
SUBMITTER: Thompson JJ
PROVIDER: S-EPMC8067673 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Thompson Joshua J JJ Short Sarah P SP Parang Bobak B Brown Rachel E RE Li Chenxuan C Ng Victoria H VH Saito-Diaz Kenyi K Choksi Yash A YA Washington Mary K MK Smith Jesse Joshua JJ Fingleton Barbara B Brand Thomas T Lee Ethan E Coffey Robert J RJ Williams Christopher S CS
Carcinogenesis 20190901 9
Blood vessel epicardial substance (BVES, otherwise known as POPDC1) is an integral membrane protein known to regulate tight junction formation and epithelial-mesenchymal transition. BVES is underexpressed in a number of malignancies, including colorectal cancer. BVES loss leads to activation of the Wnt pathway, suggesting that decreased BVES expression functionally contributes to tumorigenesis. However, the mechanism by which BVES modulates Wnt signaling is unknown. Here, we confirm that BVES lo ...[more]