Determination of Colistin in Contents Derived from Gastrointestinal Tract of Feeding Treated Piglet and Broiler.

ABSTRACT: Colistin is considered as the last-resort treatment for multiantibiotic-resistant Gram-negative bacterial infections in humans. However, the oral administration of colistin to livestock and poultry results in the introduction of large amounts of colistin to the surrounding environment via urine and feces, potentially inducing the prevalence of colistin-resistant bacteria and the impact on the ecological environment. We established a quantitative mass spectrometry (MS) based method to measure colistin in contents recovered from the gastrointestinal segments of piglets and broilers, as well as colistin in feces from the animals. The mean recoveries of colistin from different matrices were between 73.2% and 103.9%. The quantitation limit values for different matrices ranged from 0.37 to 1.85

SUBMITTER: Peng C 

PROVIDER: S-EPMC8070394 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature