Design, Synthesis, and Validation of a Novel [11C]Promethazine PET Probe for Imaging Abeta Using Autoradiography.
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ABSTRACT:
SUBMITTER: Whitmore CA
PROVIDER: S-EPMC8070574 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Design, Synthesis, and Validation of a Novel [<sup>11</sup>C]Promethazine PET Probe for Imaging Abeta Using Autoradiography.
Whitmore Clayton A CA Boules Mariam I MI Behof William J WJ Haynes Justin R JR Koktysh Dmitry D Rosenberg Adam J AJ Tantawy Mohammed N MN Pham Wellington W
Molecules (Basel, Switzerland) 20210410 8
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer's disease. However, so far, all of the studies were performed in vitro using extracted tissues. In this work, we report the design and synthesis of a novel [<sup>11</sup>C]promethazine PET radioligand for future in vivo studies. The [<sup>11</sup>C]promethazine was isolated by RP-HPLC with radiochemical purity >95% and molar activi ...[more]
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