Ontology highlight
ABSTRACT:
SUBMITTER: Gauckler P
PROVIDER: S-EPMC8071613 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Gauckler Philipp P Shin Jae Il JI Alberici Federico F Audard Vincent V Bruchfeld Annette A Busch Martin M Cheung Chee Kay CK Crnogorac Matija M Delbarba Elisa E Eller Kathrin K Faguer Stanislas S Galesic Kresimir K Griffin Siân S van den Hoogen Martijn W F MWF Hrušková Zdenka Z Jeyabalan Anushya A Karras Alexandre A King Catherine C Kohli Harbir Singh HS Mayer Gert G Maas Rutger R Muto Masahiro M Moiseev Sergey S Odler Balazs B Pepper Ruth J RJ Quintana Luis F LF Radhakrishnan Jai J Ramachandran Raja R Salama Alan D AD Schönermarck Ulf U Segelmark Mårten M Smith Lee L Tesař Vladimír V Wetzels Jack J Willcocks Lisa L Windpessl Martin M Zand Ladan L Zonozi Reza R Kronbichler Andreas A
Kidney international reports 20210113 4
Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has been investigated in several studies, including 3 randomized controlled trials, in which complete and partial remission of proteinuria was achiev ...[more]