Unknown

Dataset Information

0

Lipid-protein forces predict conformational changes in a mechanosensitive channel.


ABSTRACT: The mechanosensitive TREK-2 potassium channel, a member of the K2P family, has essential physiological roles and is, therefore, a pharmaceutical target. A combination of experimental and computational studies have established that of the two known conformations, "up" and "down", membrane tension directly favors the "up" state, which displays a higher conductance. However, these studies did not reveal the exact mechanism by which the membrane affects the channel conformation. In this work, we show that changes in protein-lipid interaction patterns suffice in predicting this conformational change, and pinpoint potentially important residues involved in this phenomenon.

SUBMITTER: Daday C 

PROVIDER: S-EPMC8071793 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4764502 | biostudies-literature
| S-EPMC3023395 | biostudies-literature
| S-EPMC9532583 | biostudies-literature
| S-EPMC8137935 | biostudies-literature
| S-EPMC5030285 | biostudies-literature
| S-EPMC7195391 | biostudies-literature
| S-EPMC7442641 | biostudies-literature
| S-EPMC5232892 | biostudies-literature
| S-EPMC6904872 | biostudies-literature
| S-EPMC7376121 | biostudies-literature