Ontology highlight
ABSTRACT:
SUBMITTER: Langerman J
PROVIDER: S-EPMC8072027 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Langerman Justin J Lopez David D Pellegrini Matteo M Smale Stephen T ST
Stem cell reports 20210325 4
CpG islands often exhibit low DNA methylation, high histone H3 lysine 4 trimethylation, low nucleosome density, and high DNase I hypersensitivity, yet the rules by which CpG islands are sensed remain poorly understood. In this study, we first evaluated the relationships between the DNA and the chromatin properties of CpG islands in embryonic stem cells using modified bacterial artificial chromosomes. Then, using a bioinformatic approach, we identified strict CpG-island density and length thresho ...[more]