Unraveling the Developmental Roadmap toward Human Brown AdiposeTissue.
Ontology highlight
ABSTRACT:
SUBMITTER: Carobbio S
PROVIDER: S-EPMC8072174 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:We have developed and characterised functionally and molecularly a new chemically-defined protocol for the differentiation of human pluripotent stem cells (hPSCs) into brown adipocytes (BAs) that overcomes current limitations This protocol recapitulates step-by-step the physiological developmental path of human BAT. The BAs obtained expresses brown adipocyte and thermogenic markers, are insulin sensitive, and responsive to β-adrenergic stimuli. This new protocol is scalable, enabling the study of human BAs at early stages of development.
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Project description:Unravelling the developmental roadmap towards human brown adipose tissue
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