Ontology highlight
ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC8072916 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Dong Yawen Y Wong Jeffrey Sum Lung JSL Sugimura Ryohichi R Lam Ka-On KO Li Bryan B Kwok Gerry Gin Wai GGW Leung Roland R Chiu Joanne Wing Yan JWY Cheung Tan To TT Yau Thomas T
Cancers 20210418 8
Advanced, unresectable hepatocellular carcinoma has a dismal outcome. Multiple immune checkpoint inhibitors (ICIs) targeting the programmed-cell death 1 pathway (PD-1/L1) have been approved for the treatment of advanced HCC. However, outcomes remain undesirable and unpredictable on a patient-to-patient basis. The combination of anti-PD-1/L1 with alternative agents, chiefly cytotoxic T-lymphocyte antigen-4 (CTLA-4) ICIs or agents targeting other oncogenic pathways such as the vascular endothelial ...[more]