Ontology highlight
ABSTRACT:
SUBMITTER: Merida-Floriano A
PROVIDER: S-EPMC8072944 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Mérida-Floriano Angela A Rowe Will P M WPM Casadesús Josep J
Cells 20210419 4
A bioinformatic search for LexA boxes, combined with transcriptomic detection of loci responsive to DNA damage, identified 48 members of the SOS regulon in the genome of <i>Salmonella enterica</i> serovar Typhimurium. Single cell analysis using fluorescent fusions revealed that heterogeneous expression is a common trait of SOS response genes, with formation of SOS<sup>OFF</sup> and SOS<sup>ON</sup> subpopulations. Phenotypic cell variants formed in the absence of external DNA damage show gene ex ...[more]