EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer.
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ABSTRACT:
SUBMITTER: Kim SH
PROVIDER: S-EPMC8073943 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Obtained tumors xenografts were profiled in two independent experiments using Affymetrix U133A arrays. Most abundant gene pattern associated with radioresistant phenotype was presented by IFN-inducible, Stat1-dependent pathway. In these experiments we detected genes responding to IFN alpha, beta and gamma in nu61 and SCC61 Keywords: Pair-wise comparison of un-treated and treated tumor cell lines
2007-11-28 | GSE9714 | GEO