Radiomics of ¹⁸F Fluorodeoxyglucose PET/CT Images Predicts Severe Immune-related Adverse Events in Patients with NSCLC.

ABSTRACT:

Purpose

To investigate the performance of pretreatment fluorine 18 (¹⁸F) fluorodeoxyglucose PET/CT radiomics in predicting severe immune-related adverse events (irSAEs) among patients with advanced non-small cell lung cancer (NSCLC) treated with immunotherapy, which is important in optimizing treatment plans and alleviating future complications with early interventions.

Materials and methods

The retrospective arm of this study included 146 patients with histologically confirmed stage IIIB-IV NSCLC who were treated with immune checkpoint blockade between June 2011 and December 2017 and who were split into training (n = 97) and test (n = 49) cohorts. A prospective validation arm enrolled 48 patients before initiation of immunotherapy between January 20

SUBMITTER: Mu W 

PROVIDER: S-EPMC8074998 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature