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Quality of life and long-term outcomes after hospitalization for COVID-19: Protocol for a prospective cohort study (Coalition VII).


ABSTRACT:

Introduction

The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil.

Methods

This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include all-cause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes.

Ethics and dissemination

The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.

SUBMITTER: Rosa RG 

PROVIDER: S-EPMC8075344 | biostudies-literature | 2021 Jan-Mar

REPOSITORIES: biostudies-literature

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Publications

Quality of life and long-term outcomes after hospitalization for COVID-19: Protocol for a prospective cohort study (Coalition VII).

Rosa Regis Goulart RG   Robinson Caroline Cabral CC   Veiga Viviane Cordeiro VC   Cavalcanti Alexandre Biasi AB   Azevedo Luciano César Pontes de LCP   Machado Flávia Ribeiro FR   Berwanger Otavio O   Avezum Álvaro Á   Lopes Renato Delascio RD   Lisboa Thiago Costa TC   Teixeira Cassiano C   Zampieri Fernando Godinho FG   Tomazini Bruno Martins BM   Kawano-Dourado Letícia L   Schneider Daniel D   Souza Denise de D   Santos Rosa da Rosa Minho Dos RDRMD   Silva Sabrina Souza da SSD   Trott Geraldine G   Gimenes Bruna Dos Passos BDP   Souza Ana Paula de AP   Barroso Bruna Machado BM   Costa Lauren Sezerá LS   Brognoli Liége Gregoletto LG   Pelliccioli Melissa Pezzetti MP   Studier Nicole Dos Santos NDS   Schardosim Raíne Fogliati de Carli RFC   Haubert Tainá Aparecida TA   Pallaoro Victoria Emanuele Lobo VEL   Oliveira Debora Mariani de DM   Velho Pedro Isaacsson PI   Medeiros Gregory Saraiva GS   Gazzana Marcelo Basso MB   Zavascki Alexandre Prehn AP   Pitrez Paulo Márcio PM   Oliveira Roselaine Pinheiro de RP   Polanczyk Carisi Anne CA   Nasi Luiz Antônio LA   Hammes Luciano Serpa LS   Falavigna Maicon M  

Revista Brasileira de terapia intensiva 20210101 1


<h4>Introduction</h4>The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil.<h4>Methods</h4>This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspec  ...[more]

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