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ABSTRACT: Introduction
The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil.Methods
This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include all-cause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes.Ethics and dissemination
The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.
SUBMITTER: Rosa RG
PROVIDER: S-EPMC8075344 | biostudies-literature | 2021 Jan-Mar
REPOSITORIES: biostudies-literature
Rosa Regis Goulart RG Robinson Caroline Cabral CC Veiga Viviane Cordeiro VC Cavalcanti Alexandre Biasi AB Azevedo Luciano César Pontes de LCP Machado Flávia Ribeiro FR Berwanger Otavio O Avezum Álvaro Á Lopes Renato Delascio RD Lisboa Thiago Costa TC Teixeira Cassiano C Zampieri Fernando Godinho FG Tomazini Bruno Martins BM Kawano-Dourado Letícia L Schneider Daniel D Souza Denise de D Santos Rosa da Rosa Minho Dos RDRMD Silva Sabrina Souza da SSD Trott Geraldine G Gimenes Bruna Dos Passos BDP Souza Ana Paula de AP Barroso Bruna Machado BM Costa Lauren Sezerá LS Brognoli Liége Gregoletto LG Pelliccioli Melissa Pezzetti MP Studier Nicole Dos Santos NDS Schardosim Raíne Fogliati de Carli RFC Haubert Tainá Aparecida TA Pallaoro Victoria Emanuele Lobo VEL Oliveira Debora Mariani de DM Velho Pedro Isaacsson PI Medeiros Gregory Saraiva GS Gazzana Marcelo Basso MB Zavascki Alexandre Prehn AP Pitrez Paulo Márcio PM Oliveira Roselaine Pinheiro de RP Polanczyk Carisi Anne CA Nasi Luiz Antônio LA Hammes Luciano Serpa LS Falavigna Maicon M
Revista Brasileira de terapia intensiva 20210101 1
<h4>Introduction</h4>The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil.<h4>Methods</h4>This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspec ...[more]