Cognitive Effects of Aerobic Exercise in Alzheimer's Disease: A Pilot Randomized Controlled Trial.

ABSTRACT:

Background

Aerobic exercise has shown inconsistent cognitive effects in older adults with Alzheimer's disease (AD) dementia.

Objective

To examine the immediate and longitudinal effects of 6-month cycling on cognition in older adults with AD dementia.

Methods

This randomized controlled trial randomized 96 participants (64 to cycling and 32 to stretching for six months) and followed them for another six months. The intervention was supervised, moderate-intensity cycling for 20-50 minutes, 3 times a week for six months. The control was light-intensity stretching. Cognition was assessed at baseline, 3, 6, 9, and 12 months using the AD Assessment Scale-Cognition (ADAS-Cog). Discrete cognitive domains were measured using the AD Uniform Data Set battery.

Results

The p

SUBMITTER: Yu F 

PROVIDER: S-EPMC8075384 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature