Can a Peritoneal Conduit Become an Artery?

ABSTRACT:

Objective

Current vascular grafts all have limitations. This study examined peritoneum as a potential graft material and the in vivo transfer of peritoneum into a functional artery like conduit after end to end anastomosis into the common carotid artery of sheep. The aim was to investigate whether implantation of a peritoneal tube into the arterial tree results in a structure with function, histological findings, and gene expression like an artery, and whether such arterialisation occurs through a conversion of the phenotype of peritoneal cells or from host cell migration into the implant.

Methods

Peritoneum with adherent rectus aponeurosis from sheep was used to form tubular vascular grafts that were implanted into the common carotid artery of six sheep, then removed

SUBMITTER: Davik P 

PROVIDER: S-EPMC8077027 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature