Variability of Thyroid Measurements from Ultrasound and Laboratory in a Repeated Measurements Study.

ABSTRACT:

Background

Variability of measurements in medical research can be due to different sources. Quantification of measurement errors facilitates probabilistic sensitivity analyses in future research to minimize potential bias in epidemiological studies. We aimed to investigate the variation of thyroid-related outcomes derived from ultrasound (US) and laboratory analyses in a repeated measurements study.

Subjects and methods

Twenty-five volunteers (13 females, 12 males) aged 22-70 years were examined once a month over 1 year. US measurements included thyroid volume, goiter, and thyroid nodules. Laboratory measurements included urinary iodine concentrations and serum levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and thyroglobulin.

SUBMITTER: Ittermann T 

PROVIDER: S-EPMC8077478 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature