Association of Dysregulated Central Pain Processing and Response to Disease-Modifying Antirheumatic Drug Therapy in Rheumatoid Arthritis.

ABSTRACT:

Objective

To determine the association between dysregulated central pain processing and treatment response in rheumatoid arthritis (RA).

Methods

One hundred eighty-two participants with active RA were followed up for 12 weeks after starting a disease-modifying antirheumatic drug (DMARD). To assess central pain processing, participants underwent quantitative sensory testing (QST), including assessment of pressure pain thresholds (PPTs) at the trapezius muscles, temporal summation, and conditioned pain modulation (CPM). QST measures were categorized as high central dysregulation versus low central dysregulation. The association between baseline central dysregulation and treatment response, as defined by the European League Against Rheumatism (EULAR) response criteria, was asse

SUBMITTER: Heisler AC 

PROVIDER: S-EPMC8078061 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature