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Accuracy of digital dental models and three-dimensional printed dental models in linear measurements and Bolton analysis.

ABSTRACT: Background: Due to advances in digital technology, it is possible to obtain digital dental models through intraoral scanning. The stereolithographic data collected from the scanner can subsequently be printed into a three-dimensional dental model in resinic material. However, the accuracy between digital dental models and printed dental models needs to be evaluated since it might affect diagnosis and treatment planning in orthodontic treatment. This study aimed to evaluate the accuracy of digital models scanned by a Trios intraoral scanner and three-dimensional dental models printed using a Formlabs 2 3D printer in linear measurements and Bolton analysis. Methods: A total of 35 subjects were included in this study. All subjects were scanned using a Trios intraoral scanner to obtain digital study models. Stereolithographic data from previous scanning was printed using a Formlabs 2 3D printer to obtain printed study models. Mesiodistal, intercanine, intermolar, and Bolton analysis from all types of study models were measured. The intraclass correlation coefficient was used to assess intraobserver and interobserver reliability. All data were then statistically analyzed. Results: The reliability tests were high for both intraobserver and interobserver reliability, which demonstrates high reproducibility for all measurements on all model types. Most of the data compared between study models showed no statistically significant differences, though some data differed significantly. However, the differences are considered clinically insignificant. Conclusion: Digital dental models and three-dimensional printed dental models may be used interchangeably with plaster dental models for diagnostic and treatment planning purposes. Keywords: Accuracy, 3D printing, digital dental model, printed dental model.

SUBMITTER: Suryajaya W

PROVIDER: S-EPMC8078212 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Assessing skin irritation potential is critical for the safety evaluation of topical drugs and other consumer products such as cosmetics. The use of advanced cellular models, as an alternative to replace animal testing in the safety evaluation for both consumer products and ingredients, is already mandated by law in the European Union (EU) and other countries. However, there has not yet been a large-scale comparison of the effects of topical-use compounds in different cellular skin models. This study assesses the irritation potential of topical-use compounds in different cellular models of the skin that are compatible with high throughput screening (HTS) platforms. A set of 451 topical-use compounds were first tested for cytotoxic effects using two-dimensional (2D) monolayer models of primary neonatal keratinocytes and immortalized human keratinocytes. Forty-six toxic compounds identified from the initial screen with the monolayer culture systems were further tested for skin irritation potential on reconstructed human epidermis (RhE) and full thickness skin (FTS) three-dimensional (3D) tissue model constructs. Skin irritation potential of the compounds was assessed by measuring tissue viability, trans-epithelial electrical resistance (TEER), and secretion of cytokines interleukin 1 alpha (IL-1α) and interleukin 18 (IL-18). Among known irritants, high concentrations of methyl violet and methylrosaniline decreased viability, lowered TEER, and increased IL-1α secretion in both RhE and FTS models, consistent with irritant properties. However, at low concentrations, these two compounds increased IL-18 secretion without affecting levels of secreted IL-1α, and did not reduce tissue viability and TEER, in either RhE or FTS models. This result suggests that at low concentrations, methyl violet and methylrosaniline have an allergic potential without causing irritation. Using both HTS-compatible 2D cellular and 3D tissue skin models, together with irritation relevant activity endpoints, we obtained data to help assess the irritation effects of topical-use compounds and identify potential dermal hazards.

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Accuracy of digital dental models and three-dimensional printed dental models in linear measurements and Bolton analysis.

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