Hydroxocobalamin in Refractory Septic Shock: A Retrospective Case Series.
Ontology highlight
ABSTRACT: Design
Single-center, retrospective analysis.Setting
Urban, tertiary-care ICU.Patients
Adult ICU patients with refractory septic shock treated with hydroxocobalamin between August 2018 and January 2020.Interventions
Hydroxocobalamin 5 g IV infusion.Measurements and main results
Twenty-six patients were included for the analysis. Administration of hydroxocobalamin was associated with an increase in mean arterial pressure at 1, 6, and 24 hours postdose (+16.3, +14.3, and +16.3 mm Hg, respectively; p < 0.001). Increase in mean arterial pressure from baseline remained statistically significant when controlling for sex, age, and comorbid conditions. There was no change in the norepinephrine equivalents patients required 1 hour following hydroxocobalamin administration, but a statistically significant decrease in norepinephrine equivalent was observed at 6 and 24 hours postdose (p < 0.001).Conclusions
Hydroxocobalamin provides sustained hemodynamic benefit at 24 hours in patients with refractory septic shock.
SUBMITTER: Sacco AJ
PROVIDER: S-EPMC8078293 | biostudies-literature |
REPOSITORIES: biostudies-literature
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2007-06-14 | GSE8121 | GEO
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