Varied clinical significance of ATP-binding cassette C sub-family members for lung adenocarcinoma.

ABSTRACT:

Abstract

Lung adenocarcinoma (LUAD) is a lethal malignancy worldwide and a major public health concern. We explored the potential clinical significance for LUAD of ATP-binding cassette (ABC), sub-family C, consisting of ABCC1-6, 8-12, and cystic fibrosis transmembrane conductance regulator (CFTR).Five hundred LUAD patients from The Cancer Genome Atlas database were used for analysis, including differential expression and diagnostic and prognostic significance. Oncomine and MERAV databases were used to validate differential expression and diagnostic significance. A risk score model was constructed using prognosis-related ABCC members. Prognosis-related genes were further explored to correlate their expression with tumor stage progression. Interaction networks, including biological p

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8078454 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature