A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons.

ABSTRACT: Macroautophagy/autophagy cytoplasmic quality control pathways are required during neural development and are critical for the maintenance of functional neuronal populations in the adult brain. Robust evidence now exists that declining neuronal autophagy pathways contribute to human neurodegenerative diseases, including Parkinson disease (PD). Reliable and relevant human neuronal model systems are therefore needed to understand the biology of disease-vulnerable neural populations, to decipher the underlying causes of neurodegenerative disease, and to develop assays to test therapeutic interventions in vitro. Human induced pluripotent stem cell (hiPSC) neural model systems can meet this demand: they provide a renewable source of material for differentiation into regional neuronal sub-

SUBMITTER: Stathakos P 

PROVIDER: S-EPMC8078667 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature