Tumor-targeted Gd-doped mesoporous Fe₃O₄ nanoparticles for T₁/T₂ MR imaging guided synergistic cancer therapy.

ABSTRACT: In this study, a novel intelligent nanoplatform to integrate multiple imaging and therapeutic functions for targeted cancer theranostics. The nanoplatform, DOX@Gd-MFe₃O₄ NPs, was constructed Gd-doped mesoporous Fe₃O₄ nanoparticles following with the doxorubicin (DOX) loading in the mesopores of the NPs. The DOX@Gd-MFe₃O₄ NPs exhibited good properties in colloidal dispersity, photothermal conversion, NIR triggered drug release, and high T₁/T₂ relaxicity rate (r₁=9.64 mM^-1s^-1, r₂= 177.71 mM^-1s^-1). Benefiting from the high MR contrast, DOX@Gd-MFe₃O₄ NPs enabled simultaneous T₁/T₂ dual

SUBMITTER: Zheng S 

PROVIDER: S-EPMC8079076 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature