Ontology highlight
ABSTRACT:
SUBMITTER: Skolnick J
PROVIDER: S-EPMC8079554 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Current opinion in structural biology 20201028
The tertiary structure of a native protein is dictated by the interplay of local secondary structure propensities, hydrogen bonding, and tertiary interactions. It is argued that the space of known protein topologies covers all single domain folds and results from the compactness of the native structure and excluded volume. Protein compactness combined with the chirality of the protein's side chains also yields native-like Ramachandran plots. It is the many-body, tertiary interactions among resid ...[more]