Ontology highlight
ABSTRACT:
SUBMITTER: Duner P
PROVIDER: S-EPMC8079692 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Dunér Pontus P Mattisson Ingrid Yao IY Fogelstrand Per P Glise Lars L Ruiz Stacey S Farina Christopher C Borén Jan J Nilsson Jan J Bengtsson Eva E
Scientific reports 20210427 1
Atherosclerotic plaques are characterized by an accumulation and subsequent oxidation of LDL, resulting in adaptive immune responses against formed or exposed neoepitopes of the LDL particle. Autoantibodies against native p210, the 3136-3155 amino acid sequence of the LDL protein apolipoprotein B-100 (apoB100) are common in humans and have been associated with less severe atherosclerosis and decreased risk for cardiovascular events in clinical studies. However, whether apoB100 native p210 autoan ...[more]