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Cu/SiO₂-Pr-NH-Benz as a novel nanocatalyst for the efficient synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives in an aqueous solution.

ABSTRACT: In this work, an innovative nanocatalyst (Cu/SiO₂-Pr-NH-Benz) was synthesized and applied to coupling and click reaction in an aqueous solution. This work reports an efficient and straightforward approach for synthesizing diverse propargylamine and 1,2,3-triazole derivatives in excellent yield and short-time reaction. Also, a novel method involving the Cu NPs supported on the SiO₂ nanocatalyst as a heterogeneous novel catalyst for the "one-pot" three-component A³-coupling of aldehyde, amine, and alkynes and "one-pot" click reaction between alkyne, benzyl halide, and sodium azide in the water at room temperature was developed. Significant advantageous such as enhanced catalytic activity with efficient recycling for the one-pot synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives and in green condition were observed. Also, after five successive reactions, the catalytic activity of recycled Cu/SiO₂-Pr-NH-Benz remained high without significant loss in its intrinsic activity.

SUBMITTER: Darroudi M

PROVIDER: S-EPMC8080054 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundUnderstanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nanoparticles not only help to unravel unknown toxicological mechanism but also contribute to the possible biological applications of nanomaterial.MethodsIn this study, the biodistribution and the size-dependent biological effects of Fe3O4@SiO2-NH2 nanoparticles (Fe@Si-NPs) in three diameters (10, 20 and 40 nm) were investigated by ICP-AES, serum biochemistry analysis and NMR-based metabolomic analysis after intravenous administration in a rat model.ResultsOur findings indicated that biodistribution and biological activities of Fe@Si-NPs demonstrated the obvious size-dependent and tissue-specific effects. Spleen and liver are the target tissues of Fe@Si-NPs, and 20 nm of Fe@Si-NPs showed a possible longer blood circulation time. Quantitative biochemical analysis showed that the alterations of lactate dehydrogenase (LDH) and uric acid (UA) were correlated to some extent with the sizes of Fe@Si-NPs. The untargeted metabolomic analyses of tissue metabolomes (kidney, liver, lung, and spleen) indicated that different sizes of Fe@Si-NPs were involved in the different biochemical mechanisms. LDH, formate, uric acid, and GSH related metabolites were suggested as sensitive indicators for the size-dependent toxic effects of Fe@Si-NPs. The findings from serum biochemical analysis and metabolomic analysis corroborate each other. Thus we proposed a toxicity hypothesis that size-dependent NAD depletion may occur in vivo in response to nanoparticle exposure. To our knowledge, this is the first report that links size-dependent biological effects of nanoparticles with in vivo NAD depletion in rats.ConclusionThe integrated metabolomic approach is an effective tool to understand physiological responses to the size-specific properties of nanoparticles. Our results can provide a direction for the future biological applications of Fe@Si-NPs.

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Cu/SiO₂-Pr-NH-Benz as a novel nanocatalyst for the efficient synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives in an aqueous solution.

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Cu/SiO2-Pr-NH-Benz as a novel nanocatalyst for the efficient synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives in an aqueous solution.

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OmicsDI is part of the ELIXIR infrastructure

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Cu/SiO₂-Pr-NH-Benz as a novel nanocatalyst for the efficient synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives in an aqueous solution.