Ontology highlight
ABSTRACT:
SUBMITTER: van der Kolk BW
PROVIDER: S-EPMC8080113 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
van der Kolk Birgitta W BW Saari Sina S Lovric Alen A Arif Muhammad M Alvarez Marcus M Ko Arthur A Miao Zong Z Sahebekhtiari Navid N Muniandy Maheswary M Heinonen Sini S Oghabian Ali A Jokinen Riikka R Jukarainen Sakari S Hakkarainen Antti A Lundbom Jesper J Kuula Juho J Groop Per-Henrik PH Tukiainen Taru T Lundbom Nina N Rissanen Aila A Kaprio Jaakko J Williams Evan G EG Zamboni Nicola N Mardinoglu Adil A Pajukanta Päivi P Pietiläinen Kirsi H KH
Cell reports. Medicine 20210330 4
Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, adipose tissue appears to be more affected by excess body weight than skeletal muscle. In heavier co-twins, we observe a transcriptional pattern of downregulated mitochondrial pathways in both tissues and upregulate ...[more]