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Facile Pyridine S _N Ar Reactions via N-Phosphonium-Pyridinium Intermediates.

ABSTRACT: Here we report that N-phosphonium pyridinium intermediates are unusually reactive for pyridine S _N Ar reactions. Specifically, forming phosphonium salts from halopyridines typically requires elevated temperatures and Lewis acid additives. The alternative activation mode described in this paper permits C-P bond formation to occur at ambient temperatures in many cases, and functions across a broad range of substrates.

SUBMITTER: Boyle BT

PROVIDER: S-EPMC8081384 | biostudies-literature |

REPOSITORIES: biostudies-literature

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