Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC8081565 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wang Rui R Bing Ante A Wang Cathy C Hu Yuchen Y Bosch Ronald J RJ DeGruttola Victor V
Statistics in medicine 20200415 15
Characterization of HIV viral rebound after the discontinuation of antiretroviral therapy is central to HIV cure research. We propose a parametric nonlinear mixed effects model for the viral rebound trajectory, which often has a rapid rise to a peak value followed by a decrease to a viral load set point. We choose a flexible functional form that captures the shapes of viral rebound trajectories and can also provide biological insights regarding the rebound process. Each parameter can incorporate ...[more]