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The ¹H, ¹⁵N, and ¹³C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus.

ABSTRACT: During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcriptional regulatory sequence (TRS) and is involved in the discontinuous transcription through the melting activity of double-stranded TRS (dsTRS).

SUBMITTER: de Araujo TS

PROVIDER: S-EPMC8082218 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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The 1H, 15N, and 13C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus.

de Araujo Talita Stelling TS Barbosa Glauce Moreno GM Sanches Karoline K Azevedo Jéssica M JM Dos Santos Cabral Katia Maria KM Almeida Marcius S MS Almeida Fabio C L FCL

Biomolecular NMR assignments 20210429 2

During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcri ...[more]

PMID: 33914244

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