Characteristics of epigenetic aging across gestational and perinatal tissues.

ABSTRACT:

Background

Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns-especially regarding different gestational or perinatal tissues. In this study, we investigated which birth- and pregnancy-related variables are most important in predicting gestational epigenetic age acceleration or deceleration (i.e., the deviation between gestational epigenetic age estimated from the DNA methylome and chronological gestational age) in chorionic villus, placenta and cord blood tissues from two independent study cohorts (ITU, n = 639 and PREDO, n = 966). We further characterized the correspondence of epigenetic age deviations between these tissues.

Res

SUBMITTER: Dieckmann L 

PROVIDER: S-EPMC8082803 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature