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Macrocyclic Ligands with an Unprecedented Size-Selectivity Pattern for the Lanthanide Ions.

ABSTRACT: Lanthanides (Ln³⁺) are critical materials used for many important applications, often in the form of coordination compounds. Tuning the thermodynamic stability of these compounds is a general concern, which is not readily achieved due to the similar coordination chemistry of lanthanides. Herein, we report two 18-membered macrocyclic ligands called macrodipa and macrotripa that show for the first time a dual selectivity toward both the light, large Ln³⁺ ions and the heavy, small Ln³⁺ ions, as determined by potentiometric titrations. The lanthanide complexes of these ligands were investigated by NMR spectroscopy and X-ray crystallography, which revealed the occurrence of a significant conformational toggle between a 10-coordinate Conformation A and an 8-coordinate Conformation B that accommodates Ln³⁺ ions of different sizes. The origin of this selectivity pattern was further supported by density functional theory (DFT) calculations, which show the complementary effects of ligand strain energy and metal-ligand binding energy that contribute to this conformational switch. This work demonstrates how novel ligand design strategies can be applied to tune the selectivity pattern for the Ln³⁺ ions.

SUBMITTER: Hu A

PROVIDER: S-EPMC8084257 | biostudies-literature |

REPOSITORIES: biostudies-literature

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