Diversity and Functions of Type II Topoisomerases.
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ABSTRACT:
SUBMITTER: Sutormin DA
PROVIDER: S-EPMC8084294 | biostudies-literature | 2021 Jan-Mar
REPOSITORIES: biostudies-literature
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Diversity and Functions of Type II Topoisomerases.
Sutormin D A DA Galivondzhyan A K AK Polkhovskiy A V AV Kamalyan S O SO Severinov K V KV Dubiley S A SA
Acta naturae 20210101 1
The DNA double helix provides a simple and elegant way to store and copy genetic information. However, the processes requiring the DNA helix strands separation, such as transcription and replication, induce a topological side-effect - supercoiling of the molecule. Topoisomerases comprise a specific group of enzymes that disentangle the topological challenges associated with DNA supercoiling. They relax DNA supercoils and resolve catenanes and knots. Here, we review the catalytic cycles, evolutio ...[more]
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