Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications.

ABSTRACT: Osteoporosis is a common skeletal disease, affecting ~200 million people around the world. As a complex disease, osteoporosis is influenced by many factors, including diet (e.g. calcium and protein intake), physical activity, endocrine status, coexisting diseases and genetic factors. In this review, we first summarize the discovery from genome-wide association studies (GWASs) in the bone field in the last 12 years. To date, GWASs and meta-analyses have discovered hundreds of loci that are associated with bone mineral density (BMD), osteoporosis, and osteoporotic fractures. However, the GWAS approach has sometimes been criticized because of the small effect size of the discovered variants and the mystery of missing heritability, these two questions could be partially explained by the newly

SUBMITTER: Zhu X 

PROVIDER: S-EPMC8085014 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature