The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation.

ABSTRACT: The precise characterization of the lobular architecture of the liver has been subject of investigation since the earliest historical publications, but an accurate model to describe the hepatic lobular microanatomy is yet to be proposed. Our aim was to evaluate whether Voronoi diagrams can be used to describe the classic liver lobular architecture. We examined the histology of normal porcine and human livers and analyzed the geometric relationships of various microanatomic structures utilizing digital tools. The Voronoi diagram model described the organization of the hepatic classic lobules with overall accuracy nearly 90% based on known histologic landmarks. We have also designed a Voronoi-based algorithm of hepatic zonation, which also showed an overall zonal accuracy of nearly 90%. Ther

SUBMITTER: Lau C 

PROVIDER: S-EPMC8085188 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature