Improved chondrogenic performance with protective tracheal design of Chitosan membrane surrounding 3D-printed trachea.

ABSTRACT: In recent tracheal tissue engineering, limitations in cartilage reconstruction, caused by immature delivery of chondrocyte-laden components, have been reported beyond the complete epithelialization and integration of the tracheal substitutes with the host tissue. In an attempt to overcome such limitations, this article introduces a protective design of tissue-engineered trachea (TraCHIM) composed of a chitosan-based nanofiber membrane (CHIM) and a 3D-printed biotracheal construct. The CHIM was created from chitosan and polycaprolactone (PCL) using an electrospinning process. Upon addition of chitosan to PCL, the diameter of electrospun fibers became thinner, allowing them to be stacked more closely, thereby improving its mechanical properties. Chitosan also enhances the hydrophilicity of t

SUBMITTER: Kim H 

PROVIDER: S-EPMC8085235 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature