Browse
Submit Data
Databases
API
Help

Dataset Information

39 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Complete Genome Sequences of Two Corynebacterium macginleyi Strains Isolated from Infectious Keratitis.

ABSTRACT: Corynebacterium macginleyi is a slow-growing, lipid-requiring bacterium that may cause ocular infections. Here, we report the complete genome sequences of two strains, T160811 and T180208, isolated from infectious keratitis. The two genomes consist of circular chromosomes of 2,431,961 bp and 2,481,998 bp, respectively, and contain high numbers of repetitive elements.

SUBMITTER: Sagerfors S

PROVIDER: S-EPMC8086210 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Complete Genome Sequences of Two Corynebacterium macginleyi Strains Isolated from Infectious Keratitis.

Sagerfors Susanna S Poehlein Anja A Söderquist Bo B Brüggemann Holger H

Microbiology resource announcements 20210429 17

<i>Corynebacterium macginleyi</i> is a slow-growing, lipid-requiring bacterium that may cause ocular infections. Here, we report the complete genome sequences of two strains, T160811 and T180208, isolated from infectious keratitis. The two genomes consist of circular chromosomes of 2,431,961 bp and 2,481,998 bp, respectively, and contain high numbers of repetitive elements. ...[more]

PMID: 33927036

Similar Datasets

Clinical and genomic features of Corynebacterium macginleyi-associated infectious keratitis.

Project description:Infectious keratitis is a potentially sight threatening ophthalmological emergency. Contact lens wear is a common risk factor. Diagnostic advances such as MALDI-TOF MS provides new insights into the spectrum of corneal pathogens and on microbes previously considered as commensals. Corynebacterium macginleyi was described in 1995, and in 2018, the genomic features of three isolates were reported after whole-genome sequencing. Here we describe the clinical characteristics of patients with infectious keratitis (n = 29) presumably caused by Corynebacterium macginleyi, and analyze the genomic features of C. macginleyi (n = 22) isolated from the corneal ulcers of these patients. The disease course was uneventful apart from minor interventions such as corneal cross-linking and amniotic membrane transplant. Genome sequencing and comparison revealed a highly conserved core genome of C. macginleyi. Based on the analyses of single nucleotide polymorphisms, the population could be divided into two main clades that also differed in a few clade-specific genomic islands. Patients infected with an isolate belonging to the minor clade (n = 7) presented a more severe disease. Comparisons with other corynebacterial species clearly separated C. macginleyi. C. macginleyi may be considered a corneal pathogen; genomic analysis provided insights into its population structure and disease-causing potential.

| S-EPMC7966771 | biostudies-literature

Project description:We report two cases of suture-related keratitis following penetrating keratoplasty. In both cases, Corynebacterium macginleyi was isolated from corneal specimens. Scanning electron microscopy revealed that corynebacteria could aggregate and form a biofilm. The MICs of sulbenicillin and fluoroquinolones were high for both isolates. Our findings show that C. macginleyi can cause keratitis with biofilm formation.

| S-EPMC2168495 | biostudies-literature

Complete Genome Sequences of Two Bordetella hinzii Strains Isolated from Humans.

Project description:Bordetella hinzii is primarily recovered from poultry but can also colonize mammalian hosts and immunocompromised humans. Here, we report the first complete genome sequences of B. hinzii in two isolates recovered from humans. The availability of these sequences will hopefully aid in identifying host-specific determinants variably present within this species.

| S-EPMC4551878 | biostudies-literature

Corynebacterium macginleyi isolated from a corneal ulcer.

Project description:We report the isolation of Corynebacterium macginleyi from the corneal ulcer culture of a patient, later enrolled in the Steroids for Corneal Ulcer Trial (SCUT). To our knowledge this is the first published report from North America of the recovery of C. macginleyi from a serious ocular infection.

| S-EPMC3123035 | biostudies-literature

Complete Genome Sequences of Two Streptococcus suis Strains Isolated from Asymptomatic Pigs.

Project description:Streptococcus suis is an important zoonotic pathogen that causes major economic problems in the pig industry worldwide and serious infections in humans, including meningitis and septicemia. Here, we report the complete genome sequences of two strains isolated from asymptomatic pigs.

| S-EPMC7679101 | biostudies-literature

Complete Genome Sequences of Two Pseudomonas aeruginosa Strains Isolated from Children with Bacteremia.

Project description:Two Pseudomonas aeruginosa strains isolated from children with bacteremia in Mexico City were sequenced using PacBio RS-II single-molecule real-time (SMRT) technology. The strains consist of a 7.0- to 7.4-Mb chromosome, with a high content of mobile elements, and variation in the genetic content of class 1 integron In1409.

| S-EPMC5578860 | biostudies-literature

Complete Genome Sequences of Two Staphylococcus saccharolyticus Strains Isolated from Prosthetic Joint Infections.

Project description:Staphylococcus saccharolyticus is a human skin bacterium and is occasionally associated with prosthetic joint infections (PJIs). Here, we report the complete genome sequences of two strains that were isolated from shoulder and hip PJIs. The genomes show signs of reductive evolution; around 21% of all coding sequences are inactivated by frameshift mutations.

| S-EPMC7953294 | biostudies-literature

Complete Genome Sequences of Two Rhodobacter Strains.

Project description:We report the complete genome sequences of two strains of the Alphaproteobacteria genus Rhodobacter, Rhodobacter blasticus 28/5, the source of the commercially available enzyme RsaI, and a new isolate of Rhodobacter sphaeroides 2.4.1. Both strains contain multiple restriction-modification systems, and their DNA methylation motifs are included in this report.

| S-EPMC6256690 | biostudies-literature

Complete Genome Sequences of Two Shiga Toxin-Producing Escherichia coli Strains Isolated from Crows.

Project description:Escherichia coli strains RM9088 and RM10410 were isolated from crows near a leafy greens-growing region in California in April and July 2009, respectively. Both strains carry genes encoding Shiga toxins and other virulence factors in enteric pathogens. Here, we report the complete genome sequences of RM9088 and RM10410.

| S-EPMC6838620 | biostudies-literature

Complete Genome Sequences of Two Cutibacterium acnes Strains Isolated from an Orthopedic Surgical Site.

Project description:Cutibacterium acnes was reported as one of the most frequently isolated opportunistic pathogens among the skin microbiota. Here, we report two complete genome sequences of Cutibacterium acnes strains that were isolated from surgical (strain SZ1) and nonsurgical (strain SZ2) sites on the back of an orthopedic surgery patient.

| S-EPMC7180284 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data