Ontology highlight
ABSTRACT:
SUBMITTER: Luo K
PROVIDER: S-EPMC8086767 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Luo Kai K Luo Xianghua X Cao Wenhao W Hochalter J Bradley JB Paiano Viviana V Sipe Christopher J CJ Carmella Steven G SG Murphy Sharon E SE Jensen Joni J Lam Stephen S Golin Andrew P AP Bergstrom Lori L Midthun David D Fujioka Naomi N Hatsukami Dorothy D Hecht Stephen S SS
Carcinogenesis 20210401 4
Although it is well established that human cytochrome P450 1 family enzymes are induced by cigarette smoking through activation of the Ah receptor, it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. We gave oral doses of deuterated phenanthrene ([D10]Phe), a non-carcinogenic surrogate of carcinogenic PAH such as benzo[a]pyrene, to smokers ( ...[more]