Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits.

ABSTRACT:

Objective

Current understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large-scale brain networks remains elusive, largely due to the lack of techniques that can reveal DBS-induced activity at the whole-brain level. Using a novel 3T magnetic resonance imaging (MRI)-compatible stimulator, we investigated whole-brain effects of subthalamic nucleus (STN) stimulation in patients with Parkinson disease.

Methods

Fourteen patients received STN-DBS treatment and participated in a block-design functional MRI (fMRI) experiment, wherein stimulations were delivered during "ON" blocks interleaved with "OFF" blocks. fMRI responses to low-frequency (60Hz) and high-frequency(130Hz) STN-DBS were measured 1, 3, 6, and 12 months postsurgery. To ensure reliability, mu

SUBMITTER: Shen L 

PROVIDER: S-EPMC8087166 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature