Prednisolone treatment in acute interstitial nephritis (PRAISE) - protocol for the randomized controlled trial.

ABSTRACT:

Background

Acute interstitial nephritis (AIN) is an important and common cause of acute renal failure. There are no generally accepted guidelines for the treatment of AIN, due to the lack of prospective randomized trials. Since AIN is characterized by an enhanced immune response, immunosuppressive treatment could potentially improve prognosis by attenuating inflammation and subsequent fibrosis. Despite the limited evidence of effects of steroids and potential adverse effects, prednisolone is frequently used in the treatment of AIN and there is a strong need for clinical trials on the effects of immunosuppression, including steroids, in the treatment of AIN. We aimed to evaluate the effectiveness of prednisolone treatment in AIN, and hypothesized a positive effect of prednisolone tr

SUBMITTER: Mose FH 

PROVIDER: S-EPMC8088674 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature