Ontology highlight
ABSTRACT:
SUBMITTER: Rao J
PROVIDER: S-EPMC8091052 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Rao Jiahua J Zhou Xiang X Lu Yutong Y Zhao Huiying H Yang Yuedong Y
iScience 20210402 5
Single-cell RNA sequencing technology promotes the profiling of single-cell transcriptomes at an unprecedented throughput and resolution. However, in scRNA-seq studies, only a low amount of sequenced mRNA in each cell leads to missing detection for a portion of mRNA molecules, i.e. the dropout problem which hinders various downstream analyses. Therefore, it is necessary to develop robust and effective imputation methods for the increasing scRNA-seq data. In this study, we have developed an imput ...[more]