Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder.

ABSTRACT: Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling disorder. The only established first-line treatments for OCD are exposure and response prevention, and serotonin reuptake inhibitor medications (SRIs). However, a subset of patients fails to respond to either modality, and few experience complete remission. Beyond SRI monotherapy, antipsychotic augmentation is the only medication approach for OCD with substantial empirical support. Our incomplete understanding of the neurobiology of OCD has hampered efforts to develop new treatments or enhance extant interventions. This review focuses on several promising areas of research that may help elucidate the pathophysiology of OCD and advance treatment. Multiple studies support a significant genetic contribution to

SUBMITTER: Goodman WK 

PROVIDER: S-EPMC8091795 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature