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Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis.


ABSTRACT: (-)-Aurantioclavine (1), which contains a characteristic seven-membered ring fused to an indole ring, belongs to the azepinoindole class of fungal clavine alkaloids. Here we show that starting from a 4-dimethylallyl-l-tryptophan precursor, a flavin adenine dinucleotide (FAD)-binding oxidase and a catalase-like heme-containing protein are involved in the biosynthesis of 1. The function of these two enzymes was characterized by heterologous expression, in vitro characterization, and deuterium labeling experiments.

SUBMITTER: Chen KL 

PROVIDER: S-EPMC8092377 | biostudies-literature |

REPOSITORIES: biostudies-literature

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